- The epidemic is polarized - we have lots of young, new naïve infections (new to treatment), but with low T-cell counts, and those chronically infected who are aging.
- HIV is lifelong & relatively manageable, but there are lots of unanswered questions as the population ages; more research needs to ^be done on aspects of lifelong chronic manageable infection - what is the long-term significance of HIV, of treatments, etc? We need to investigate more. And PPD wants to work in collaborations with other to answer these kinds of questions.
- Is it the drugs, is it the virus or is it just getting old? Or a mix of the three?
- USA: 13-14% of new cases are >50 yrs
- Significant increase in older women >50 yrs
- Late presenters and not perceived to be at risk
- Divorce/Widowed-starting new relationships
- Use of other drugs in older people
- Poor immune response
- Faster disease progression
- And Differently-abled conditions
- Older age associated with:
- Better adherence
- Slower CD4 recovery
- Increased mortality from non-AIDS events